| Protein ID | Protein Name | Protein Description | Gene Name | Species | Strain | PMID |
|---|---|---|---|---|---|---|
| B0XN02 | DNA topoisomerase I | Releases the supercoiling and torsional tension of DNAintroduced during the DNA replication and transcription by transientlycleaving and rejoining one strand of the DNA duplex. Introduces asingle-strand break via transesterification at the specific target site5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester isattacked by the catalytic tyrosine of the enzyme, resulting in theformation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and theexpulsion of a 5'-OH DNA strand. The free DNA strand then undergoespassage around the unbroken strand thus removing DNA supercoils.Finally, in the religation step, the DNA 5'-OH attacks the covalentintermediate to expel the active-site tyrosine and restore the DNAphosphodiester backbone. | AFUB_003910 | Aspergillus fumigatus | ku80 | 32817450 |