| Protein ID | Protein Name | Protein Description | Gene Name | Species | Strain | PMID |
|---|---|---|---|---|---|---|
| B0YED2 | Queuine tRNA-ribosyltransferase | Catalyzes the base-exchange of a guanine (G) residue with thequeuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34(anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacementmechanism. The nucleophile active site attacks the C1' of nucleotide 34to detach the guanine base from the RNA, forming a covalent enzyme-RNAintermediate. The proton acceptor active site deprotonates the incomingPreQ1, allowing a nucleophilic attack on the C1' of the ribose to formthe product. After dissociation, two additional enzymatic reactions onthe tRNA convert PreQ1 to queuine (Q), resulting in the hypermodifiednucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). | AFUB_098770 | Aspergillus fumigatus | ku80 | 32817450 |