| Protein ID | Protein Name | Protein Description | Gene Name | Species | Strain | PMID |
|---|---|---|---|---|---|---|
| J9VHN6 | Copper acquisition factor BIM1 | Cell surface-bound protein that functions in the copper-accumulation pathway shared by the CUF1-dependent copper transporterCTR1 (PubMed:31932719). Binds Cu(2+) with an estimated 1:1stoichiometry and might serve as an extracellular copper ligand(PubMed:31932719). FRE4 and FRE7 metalloreductases probably functiontogether with CTR1 and BIM1 to liberate the Cu(2+) bound to the BIM1copper-binding site for subsequent import of Cu(+) into the cell byCTR1, via the reduction of BIM1-bound Cu(2+) to Cu(+) to reduce bindingaffinity for BIM1 but increase affinity for CTR1 (Probable).Facilitates copper acquisition in the brain of mammalian hosts and actsas a copper-dependent virulence trait in fungal meningitis(PubMed:31932719). While BIM1 plays a critical role in cryptococcalmeningitis, at least in part through its role in copper acquisition, itcould play additional roles during copper limitation or as a means toinvade and colonize host tissues in the brain, by compromising hostcarbohydrate integrity via its lytic polysaccharide monooxygenase(LPMO) activity, which has still to be determined (Probable) | CNAG_02775 | Cryptococcus neoformans | KN99alpha | Available only at bioRxviv |