| Protein ID | Protein Name | Protein Description | Gene Name | Species | Strain | PMID |
|---|---|---|---|---|---|---|
| P0CB54 | ATPase GET3 | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes andselectively binds the transmembrane domain of TA proteins in thecytosol. This complex then targets to the endoplasmic reticulum bymembrane-bound receptors, where the tail-anchored protein is releasedfor insertion. This process is regulated by ATP binding and hydrolysis.ATP binding drives the homodimer towards the closed dimer state,facilitating recognition of newly synthesized TA membrane proteins. ATPhydrolysis is required for insertion. Subsequently, the homodimerreverts towards the open dimer state, lowering its affinity for themembrane-bound receptor, and returning it to the cytosol to initiate anew round of targeting. | GET3 | Candida albicans | modified SN152 | 30296253 |