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P16467
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Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
RSY113 |
20559436
|
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P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
RSY255 |
20559436
|
|
P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
RSY782 |
20559436
|
|
P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
RSY954 |
20559436
|
|
P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
SEY6210 |
20559436
|
|
P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
SF264-1D |
20559436
|
|
P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
Snf7 |
20559436
|
|
P16467
|
Pyruvate decarboxylase isozyme 2 |
Second most abundant of three pyruvate decarboxylases (PDC1,PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate toacetaldehyde and carbon dioxide during alcoholic fermentation. Most ofthe produced acetaldehyde is subsequently reduced to ethanol, but someis required for cytosolic acetyl-CoA production for biosyntheticpathways. The enzyme is also one of five 2-oxo acid decarboxylases(PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainlyinvolved in amino acid catabolism. Here the enzyme catalyzes thedecarboxylation of amino acids, which, in a first step, have beentransaminated to the corresponding 2-oxo acids. In a third step, theresulting aldehydes are reduced to alcohols, collectively referred toas fusel oils or alcohols. Its preferred substrates are thetransaminated amino acids derived from threonine (2-oxobutanoate),norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, alsoalpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate,also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate),and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucineis no substrate. In a side-reaction the carbanionic intermediate (oractive aldehyde) generated by decarboxylation or by activation of analdehyde can react with an aldehyde via condensation (or carboligation)yielding a 2-hydroxy ketone, collectively called acyloins |
YLR134W |
Saccharomyces cerevisiae |
VPS23 |
20559436
|