| Protein ID | Protein Name | Protein Description | Gene Name | Species | Strain | PMID |
|---|---|---|---|---|---|---|
| P30952 | Malate synthase 1 | Malate synthase which takes part in the glyoxylate cycle(PubMed:1454530). MLS1 activity is essential for cells to grow on oleicacid as a sole carbon source (PubMed:11846793). Two steps of theglyoxylate cycle take place in the cytosol, the splitting of isocitrateinto succinate and glyoxylate, and the dehydrogenation of malate tooxaloacetate (PubMed:1454530). However, the formation of malate fromglyoxylate and acetyl-CoA undertaken MLS1, occurs in the peroxisomeswhen cells are grown on oleic acid (Probable). The source of acetyl-CoAbeing either peroxisomal when breaking down fatty acids, or cytosolicwhen extra-cellular two-carbon substrates are used, therefore, althoughnot strictly essential, the peroxisomal localization of MLS1 appears tobe advantageous for cells growing on oleic acid, in that acetyl-CoAproduction and utilization are thereby intimately compartmentalizedtogether to increase efficiency (Probable) | YNL117W | Saccharomyces cerevisiae | SEY6210 | 20559436 |
| P30952 | Malate synthase 1 | Malate synthase which takes part in the glyoxylate cycle(PubMed:1454530). MLS1 activity is essential for cells to grow on oleicacid as a sole carbon source (PubMed:11846793). Two steps of theglyoxylate cycle take place in the cytosol, the splitting of isocitrateinto succinate and glyoxylate, and the dehydrogenation of malate tooxaloacetate (PubMed:1454530). However, the formation of malate fromglyoxylate and acetyl-CoA undertaken MLS1, occurs in the peroxisomeswhen cells are grown on oleic acid (Probable). The source of acetyl-CoAbeing either peroxisomal when breaking down fatty acids, or cytosolicwhen extra-cellular two-carbon substrates are used, therefore, althoughnot strictly essential, the peroxisomal localization of MLS1 appears tobe advantageous for cells growing on oleic acid, in that acetyl-CoAproduction and utilization are thereby intimately compartmentalizedtogether to increase efficiency (Probable) | YNL117W | Saccharomyces cerevisiae | VPS23 | 20559436 |