|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
FBP1 |
Candida albicans |
SC5314 |
26024904
|
|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
FBP1 |
Candida albicans |
YLC294 |
26024904
|
|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
FBP1 |
Candida albicans |
YLC337 |
26024904
|
|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
FBP1 |
Candida albicans |
YLC344 |
26024904
|
|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
FBP1 |
Candida albicans |
YLC375 |
26024904
|
|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
PRA1 |
Candida albicans |
modified SN152 |
30296253
|
|
P87020
|
pH-regulated antigen PRA1 |
Cell surface protein involved in the host-parasiteinteraction during candidal infection. With MP65, represents a majorcomponent of the biofilm matrix. Sequesters zinc from host tissue andmediates leukocyte adhesion and migration. As a surface protein, bindsthe two human complement regulators CFH and CFHR1, as well asplasminogen PLG, mediates complement evasion and extra-cellular matrixinteraction and/or degradation. As a released protein, enhancescomplement control in direct vicinity of the yeast and thus generatesan additional protective layer which controls host complement attack,assisting the fungus in escaping host surveillance. Binds to hostfluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading toinhibition of complement activation. Mediates also human complementcontrol and complement evasion through binding to C4BPA, another humancomplement inhibitor, as well as through binding to host integrinalpha-M/beta-2. Decreases complement-mediated adhesion, as well asuptake of C.albicans by human macrophages |
PRA1 |
Candida albicans |
strain 11 isolated from - male patient of Institute of Hematology Arthur Siqueira Cavalcanti |
25287304
|