| Protein ID | Protein Name | Protein Description | Gene Name | Species | Strain | PMID |
|---|---|---|---|---|---|---|
| Q58Z64 | ATP-dependent RNA helicase VAD1 | ATP-dependent RNA helicase involved in mRNA turnover, andmore specifically in mRNA decapping. Is involved in G1/S DNA-damagecheckpoint recovery, probably through the regulation of thetranslational status of a subset of mRNAs. May also have a role intranslation and mRNA nuclear export (By similarity). Blocks autophagyin nutrient-rich conditions by, at least partly, binding and repressingthe expression of a set of ATG genes, including ATG3, ATG7, ATG8,ATG19, ATG20 and ATG22 (PubMed:26098573). VAD1-mediated repression ofautophagy is regulated by TOR-dependent phosphorylation of thedecapping enzyme DCP2 (PubMed:26098573). Regulates multiple virulence-associated genes (PubMed:15765146). Repression of autophagy by VAD1also regulates the pathogenesis (PubMed:26098573). | CNAG_01537 | Cryptococcus neoformans | KN99alpha | Available only at bioRxviv |